2026-06-14T03:29:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/99642025-05-29T11:21:46Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Detalle, Laurent
author
Stohr, Thomas
author
Palomo-Sanz, Concepcion
author
Piedra, Pedro A
author
Gilbert, Brian E
author
Mas-Lloret, Vicente
author
Millar, Andrena
author
Power, Ultan F
author
Stortelers, Catelijne
author
Allosery, Koen
author
Melero, Jose Antonio
author
Depla, Erik
funder
Agency for Innovation by Science and Technology (Belgica)
2020-05-08T06:44:01Z
2020-05-08T06:44:01Z
2016
Antimicrob Agents Chemother. 2015 Oct 5;60(1):6-13.
10.1128/AAC.01802-15
1098-6596
0066-4804
Antimicrobial agents and chemotherapy
26438495
http://hdl.handle.net/20.500.12105/9964
Respiratory syncytial virus (RSV) is an important causative agent of lower respiratory tract infections in infants and elderly individuals. Its fusion (F) protein is critical for virus infection. It is targeted by several investigational antivirals and by palivizumab, a humanized monoclonal antibody used prophylactically in infants considered at high risk of severe RSV disease. ALX-0171 is a trimeric Nanobody that binds the antigenic site II of RSV F protein with subnanomolar affinity. ALX-0171 demonstrated in vitro neutralization superior to that of palivizumab against prototypic RSV subtype A and B strains. Moreover, ALX-0171 completely blocked replication to below the limit of detection for 87% of the viruses tested, whereas palivizumab did so for 18% of the viruses tested at a fixed concentration. Importantly, ALX-0171 was highly effective in reducing both nasal and lung RSV titers when delivered prophylactically or therapeutically directly to the lungs of cotton rats. ALX-0171 represents a potent novel antiviral compound with significant potential to treat RSV-mediated disease.
eng
Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection
research article
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URL
https://repisalud.isciii.es/bitstreams/bc33577a-a5a2-4874-920a-928bd269b6cb/download
File
MD5
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application/pdf
GenerationAndCharacterizationOf_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/d0123520-d03b-4025-8823-378da9ea45ef/download
File
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text/plain
GenerationAndCharacterizationOf_2015.pdf.txt