2026-08-29T19:27:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/98912024-09-27T08:08:11Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Menendez-Gutierrez, Maria Piedad
author
Ricote, Mercedes
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación ProCNIC
2020-05-05T09:52:24Z
2020-05-05T09:52:24Z
2017-06
Cell Mol Life Sci. 2017; 74(12):2135-2149
10.1007/s00018-017-2458-4
1420-9071
1420-682X
Cellular and molecular life sciences : CMLS
28105491
http://hdl.handle.net/20.500.12105/9891
Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
eng
9-cis retinoic acid
Agonists
Antagonists
Bexarotene
Bone resorption
Heterodimers
Homodimers
MAFB
Osteoporosis
Permissive
Rexinoids
Skeleton
The multi-faceted role of retinoid X receptor in bone remodeling
journal article
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URL
https://repisalud.isciii.es/bitstreams/4ff5a306-40f1-46d7-a32b-f693c7d170c8/download
File
MD5
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2029554
application/pdf
Multi-facetedRoleRetinoidX_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/d3b7cf24-d2c8-4f97-a1d5-ef1a32d9e9f4/download
File
MD5
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text/plain
Multi-facetedRoleRetinoidX_2017.pdf.txt