2026-08-29T19:27:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/98912024-09-27T08:08:11Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Menendez-Gutierrez, Maria Piedad author Ricote, Mercedes author 2017-06 Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality. Cell Mol Life Sci. 2017; 74(12):2135-2149 10.1007/s00018-017-2458-4 1420-9071 1420-682X Cellular and molecular life sciences : CMLS 28105491 http://hdl.handle.net/20.500.12105/9891 9-cis retinoic acid Agonists Antagonists Bexarotene Bone resorption Heterodimers Homodimers MAFB Osteoporosis Permissive Rexinoids Skeleton The multi-faceted role of retinoid X receptor in bone remodeling