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00925njm 22002777a 4500 dc Oteo-Iglesias, Jesus author Lázaro, Edurne author Abajo Iglesias, Francisco J de author Baquero, Fernando author Campos, Jose author 2005-04 Surveillance System. A network of 32 Spanish hospitals, serving approximately 9.6 million persons, submitted antimicrobial-susceptibility data on 7,098 invasive Escherichia coli species (2001-2003). Resistance to ampicillin, cotrimoxazole, ciprofloxacin, gentamicin, and tobramycin was found at rates of 59.9%, 32.6%, 19.3%, 6.8%, and 5.3%, respectively. Resistance to multiple drugs increased from 13.8% in 2001 to 20.6% in 2003 (p <0.0001). Antimicrobial consumption data were obtained from the Spanish National Health System. In spite of decreased cephalosporin and beta-lactam use, overall extended-spectrum beta-lactamase production increased from 1.6% (2001) to 4.1% (2003) (p <0.0001), mainly due to the rising prevalence of cefotaximases. Resistance to ciprofloxacin significantly increased, mostly in community-onset infections, which coincided with a rise in community quinolone use. Cotrimoxazole resistance remained stable at approximately 30%, even though its use was dramatically reduced. Emerg Infect Dis. 2005 Apr;11(4):546-53. 10.3201/eid1104.040699 1080-6040 Emerging infectious diseases 15829192 http://hdl.handle.net/20.500.12105/9885 Antimicrobial-resistant invasive Escherichia coli, Spain