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oai:repisalud.isciii.es:20.500.12105/98822024-09-27T08:20:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Roszer, Tamas author Menendez-Gutierrez, Maria Piedad author Cedenilla, Marta author Ricote, Mercedes author 2013-09 Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism. Recent advances reveal that RXRs are important regulators of macrophages, key players in inflammatory and metabolic disorders. This review outlines the versatility of RXR action in the control of macrophage gene transcription through its heterodimerization with other NRs or through RXR homodimerization. We also highlight the potential of RXR-controlled transcriptional programs as targets for the treatment of pathologies associated with altered macrophage function, such as atherosclerosis, insulin resistance, autoimmunity, and neurodegeneration. Trends Endocrinol Metab. 2013; 24(9):460-8 10.1016/j.tem.2013.04.004 1879-3061 1043-2760 Trends in endocrinology and metabolism: TEM 23701753 http://hdl.handle.net/20.500.12105/9882 Gene transcription Inflammation Lipid metabolism Macrophage Nuclear receptors Retinoid X receptors in macrophage biology