2026-07-22T03:36:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/98762024-09-27T08:18:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Menendez-Gutierrez, Maria Piedad
author
Roszer, Tamas
author
Ricote, Mercedes
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación Genoma España
funder
Fundación La Marató TV3
funder
Ministerio de Sanidad y Consumo (España)
funder
Fundación ProCNIC
2020-05-05T08:06:40Z
2020-05-05T08:06:40Z
2012-03
Curr Top Med Chem. 2012; 12(6):548-84
10.2174/156802612799436669
1873-4294
1568-0266
Current topics in medicinal chemistry
22242855
http://hdl.handle.net/20.500.12105/9876
Peroxisome proliferator-activated receptors (PPARs) are ligand dependent transcription factors. The three mammalian PPARs are key regulators of fatty acid and lipoprotein metabolism, glucose homeostasis, cellular proliferation/ differentiation and the immune response. PPARs are therefore important targets in the treatment of metabolic disorders such as insulin resistance and type 2 diabetes mellitus, and are also of interest in relation to chronic inflammatory diseases such as atherosclerosis, arthritis, chronic pulmonary inflammation, pancreatitis, inflammatory bowel disease, and psoriasis. Recent advances have attributed novel functions to PPARs in blood pressure regulation, neuroinflammation, nerve-cell protection, inflammatory pain reduction, and the hypothalamic control of metabolism. The abundant pleiotropic actions of PPARs suggest that PPAR agonists have enormous therapeutic potential. However, current PPAR-based therapies often have undesired side effects due to the concomitant activation of PPARs in non-target cells. There is therefore growing interest in the development of cell-specific PPAR agonists and improvement of the clinical use of PPAR ligands. This review gives an overview of PPAR functions and discusses the current and potential medical implications of PPAR ligands in various pathologies, ranging from metabolic disorders to cardiovascular disease, chronic inflammation, neurodegenerative disorders and cancer.
eng
Biology and therapeutic applications of peroxisome proliferator- activated receptors
journal article
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URL
https://repisalud.isciii.es/bitstreams/dbe2fc3f-1d98-44c6-a93b-63dd0115b413/download
File
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BiologyTherapeuticApplicationsPeroxisome_2012.pdf
URL
https://repisalud.isciii.es/bitstreams/f876eb40-ba03-4c1d-b2c8-df5f8f3be49c/download
File
MD5
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BiologyTherapeuticApplicationsPeroxisome_2012.pdf.txt