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00925njm 22002777a 4500 dc Kapoor, Pooja Middha author Mavaddat, Nasim author Choudhury, Parichoy Pal author Wilcox, Amber N author Lindström, Sara author Behrens, Sabine author Michailidou, Kyriaki author Dennis, Joe author Bolla, Manjeet K author Wang, Qin author Jung, Audrey author Abu-Ful, Zomoroda author Ahearn, Thomas author Andrulis, Irene L author Anton-Culver, Hoda author Arndt, Volker author Aronson, Kristan J author Auer, Paul L author Freeman, Laura E Beane author Becher, Heiko author Beckmann, Matthias W author Beeghly-Fadiel, Alicia author Benitez, Javier author Bernstein, Leslie author Bojesen, Stig E author Brauch, Hiltrud author Brenner, Hermann author Brüning, Thomas author Cai, Qiuyin author Campa, Daniele author Canzian, Federico author Carracedo, Ángel author Carter, Brian D author Castelao, Jose E author Chanock, Stephen J author Chatterjee, Nilanjan author Chenevix-Trench, Georgia author Clarke, Christine L author Couch, Fergus J author Cox, Angela author Cross, Simon S author Czene, Kamila author Dai, James Y author Earp, H Shelton author Ekici, Arif B author Eliassen, A Heather author Eriksson, Mikael author Evans, D Gareth author Fasching, Peter A author Figueroa, Jonine author Fritschi, Lin author Gabrielson, Marike author Gago-Dominguez, Manuela author Gao, Chi author Gapstur, Susan M author Gaudet, Mia M author Giles, Graham G author González-Neira A, Anna author Guénel, Pascal author Haeberle, Lothar author Haiman, Christopher A author Håkansson, Niclas author Hall, Per author Hamann, Ute author Hatse, Sigrid author Heyworth, Jane author Holleczek, Bernd author Hoover, Robert N author Hopper, John L author Howell, Anthony author Hunter, David J author John, Esther M author Jones, Michael E author Kaaks, Rudolf author Keeman, Renske author Kitahara, Cari M author Ko, Yon-Dschun author Koutros, Stella author Kurian, Allison W author Lambrechts, Diether author Marchand, Loic Le author Lee, Eunjung author Lejbkowicz, Flavio author Linet, Martha author Lissowska, Jolanta author Llaneza, Ana author MacInnis, Robert J author Martinez, Maria Elena author Maurer, Tabea author McLean, Catriona author Neuhausen, Susan L author Newman, William G author Norman, Aaron author O'Brien, Katie M author Olshan, Andrew F author Olson, Janet E author Olsson, Håkan author Orr, Nick author Perou, Charles M author Pita, Guillermo author Polley, Eric C author Prentice, Ross L author Rennert, Gad author Rennert, Hedy S author Ruddy, Kathryn J author Sandler, Dale P author Saunders, Christobel author Schoemaker, Minouk J author Schöttker, Ben author Schumacher, Fredrick author Scott, Christopher author Scott, Rodney J author Shu, Xiao-Ou author Smeets, Ann author Southey, Melissa C author Spinelli, John J author Stone, Jennifer author Swerdlow, Anthony J author Tamimi, Rulla M author Taylor, Jack A author Troester, Melissa A author Vachon, Celine M author van Veen, Elke M author Wang, Xiaoliang author Weinberg, Clarice R author Weltens, Caroline author Willett, Walter author Winham, Stacey J author Wolk, Alicja author Yang, Xiaohong R author Zheng, Wei author Ziogas, Argyrios author Dunning, Alison M author Pharoah, Paul D P author Schmidt, Marjanka K author Kraft, Peter author Easton, Douglas F author Milne, Roger L author García-Closas, Montserrat author Chang-Claude, Jenny author 2020-05-02 We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer. J Natl Cancer Inst . 2020 ;djaa056. 10.1093/jnci/djaa056 1460-2105 0027-8874 Journal of the National Cancer Institute 32359158 http://hdl.handle.net/20.500.12105/9872 Breast cancer Epidemiology Gene-environment interactions Genetic susceptibility Polygenic risk score Risk factors Risk prediction Combined associations of a polygenic risk score and classical risk factors with breast cancer risk