2026-04-29T15:04:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/98712024-09-27T08:16:35Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Robles-Vera, Iñaki author Toral, Marta author de la Visitación, Néstor author Sánchez, Manuel author Gómez-Guzmán, Manuel author Romero, Miguel author Yang, Tao author Izquierdo-Garcia, José L author Jiménez, Rosario author Ruiz-Cabello, Jesus author Guerra-Hernández, Eduardo author Raizada, Mohan K author Perez-Vizcaino, Francisco author Duarte, Juan author 2020-03 SCOPE: The objective of this study is to determine the cardiovascular effects of the probiotics Bifidobacterium breve CECT7263 (BFM) and Lactobacillus fermentum CECT5716 (LC40), and the short chain fatty acids butyrate, and acetate in spontaneously hypertensive rats (SHR). METHODS AND RESULTS: Ten five-week old Wistar Kyoto rats (WKY) and fifty aged-matched SHR are randomly distributed into six groups: control WKY, control SHR, treated SHR-LC40, treated SHR-BMF, treated SHR-butyrate, and treated SHR-acetate. Chronic treatments with LC40 or BFM increase butyrate-producing bacteria and prevent the blood pressure increase in SHR. Oral treatment with butyrate or acetate also prevents the increase in both blood pressure and Firmicutes/Bacteroidetes (F/B) ratio. All treatments restore the Th17/Treg balance in mesenteric lymph nodes, normalized endotoxemia, and prevent the impairment of endothelium-dependent relaxation to acetylcholine, as a result of reduced NADPH oxidase-driven reactive oxygen species production. These protective effects might be mediated by both the reduction in vascular lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) pathway and the increase in Treg infiltration in the vasculature. CONCLUSION: The probiotics LC40 and BFM prevent dysbiosis and the development of endothelial dysfunction and high blood pressure in genetic hypertension. These effects seem to be related to endotoxemia reduction and to increase Treg accumulation in the vasculature. Mol Nutr Food Res. 2020; 64(6):e1900616 10.1002/mnfr.201900616 1613-4133 1613-4125 Molecular nutrition & food research 31953983 http://hdl.handle.net/20.500.12105/9871 Endothelial dysfunction Gut microbiota Hypertension Immune system Probiotic bacteria Spontaneously hypertensive rats Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids