2026-06-14T05:06:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/98182024-09-27T21:04:14Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Esher, Shannon K
author
Zaragoza, Oscar
author
Alspaugh, James Andrew
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Instituto de Salud Carlos III
2020-04-30T07:02:56Z
2020-04-30T07:02:56Z
2018
Mem Inst Oswaldo Cruz. 2018;113(7):e180057.
10.1590/0074-02760180057
1678-8060
1678-8060
Memorias do Instituto Oswaldo Cruz
29668825
http://hdl.handle.net/20.500.12105/9818
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious infections, most commonly of the central nervous system (CNS). C. neoformans is mainly found in the environment and acquired by inhalation. It could be metaphorically imagined that cryptococcal disease is a "journey" for the microorganism that starts in the environment, where this yeast loads its suitcase with virulence traits. C. neoformans first encounters the infected mammalian host in the lungs, a site in which it must choose the right elements from its "virulence suitcase" to survive the pulmonary immune response. However, the lung is often only the first stop in this journey, and in some individuals the fungal trip continues to the brain. To enter the brain, C. neoformans must "open" the main barrier that protects this organ, the blood brain barrier (BBB). Once in the brain, C. neoformans expresses a distinct set of protective attributes that confers a strong neurotropism and the ability to cause brain colonisation. In summary, C. neoformans is a unique fungal pathogen as shown in its ability to survive in the face of multiple stress factors and to express virulence factors that contribute to the development of disease.
eng
Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain
journal article
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URL
https://repisalud.isciii.es/bitstreams/672bbff9-161a-47d8-be0b-279b1b484773/download
File
MD5
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application/pdf
CryptococcalPathogenicMechanismsA_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/d7a9f947-d5c1-46cf-b18b-db4f9a44f071/download
File
MD5
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text/plain
CryptococcalPathogenicMechanismsA_2018.pdf.txt