2026-06-14T03:33:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/98082024-09-27T09:08:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Alfranca, Arantzazu
author
Campanero, Miguel R
author
Redondo, Juan Miguel
2020-04-29T14:50:04Z
2020-04-29T14:50:04Z
2018-10
Trends Mol Med. 2018; 24(10):852-37
10.1016/j.molmed.2018.08.001
1471-499X
14714914
Trends in molecular medicine
30213701
http://hdl.handle.net/20.500.12105/9808
Lentiviral vectors (LVs) transduce quiescent cells and provide stable integration to maintain transgene expression. Several approaches have been adopted to optimize LV safety profiles. Similarly, LV targeting has been tailored through strategies including the modification of envelope components, the use of specific regulatory elements, and the selection of appropriate administration routes. Models of aortic disease based on a single injection of pleiotropic LVs have been developed that efficiently transduce the three aorta layers in wild type mice. This approach allows the dissection of pathways involved in aortic aneurysm formation and the identification of targets for gene therapy in aortic diseases. LVs provide a fast, efficient, and affordable alternative to genetically modified mice to study disease mechanisms and develop therapeutic tools.
eng
Aortic aneurysm
Disease models
Gene therapy
Lentiviral vectors
Viral targeting
New Methods for Disease Modeling Using Lentiviral Vectors
journal article
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URL
https://repisalud.isciii.es/bitstreams/ce76c82a-8542-4d55-9d0c-eb2090920b68/download
File
MD5
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application/pdf
NewMethodsDiseaseModeling_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/37a3d978-49ff-4e06-a581-ba19bde17d7b/download
File
MD5
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NewMethodsDiseaseModeling_2018.pdf.txt