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00925njm 22002777a 4500 dc Alfranca, Arantzazu author Campanero, Miguel R author Redondo, Juan Miguel author 2018-10 Lentiviral vectors (LVs) transduce quiescent cells and provide stable integration to maintain transgene expression. Several approaches have been adopted to optimize LV safety profiles. Similarly, LV targeting has been tailored through strategies including the modification of envelope components, the use of specific regulatory elements, and the selection of appropriate administration routes. Models of aortic disease based on a single injection of pleiotropic LVs have been developed that efficiently transduce the three aorta layers in wild type mice. This approach allows the dissection of pathways involved in aortic aneurysm formation and the identification of targets for gene therapy in aortic diseases. LVs provide a fast, efficient, and affordable alternative to genetically modified mice to study disease mechanisms and develop therapeutic tools. Trends Mol Med. 2018; 24(10):852-37 10.1016/j.molmed.2018.08.001 1471-499X 14714914 Trends in molecular medicine 30213701 http://hdl.handle.net/20.500.12105/9808 Aortic aneurysm Disease models Gene therapy Lentiviral vectors Viral targeting New Methods for Disease Modeling Using Lentiviral Vectors