2026-05-22T17:23:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/98012024-09-27T08:43:34Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hidalgo, Andres
author
Chilvers, Edwin R
author
Summers, Charlotte
author
Koenderman, Leo
funder
Medical Research Council (Reino Unido)
funder
Wellcome Trust
funder
GlaxoSmithKline
funder
National Institute for Health Research (Reino Unido)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Dutch Research Council (Holanda)
2020-04-29T07:44:15Z
2020-04-29T07:44:15Z
2019-07
Trends Immunol. 2019; 40(7):584-597
10.1016/j.it.2019.04.013
1471-4981
1471-4906
Trends in immunology
31153737
http://hdl.handle.net/20.500.12105/9801
Neutrophils are recognized as an essential part of the innate immune response, but an active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the bone marrow through progenitor intermediaries before entering the blood, in a process that gauges the extramedullary pool size. Once believed to be directly eliminated in the marrow, liver, and spleen, neutrophils, after circulating for less than 1 day, are now known to redistribute into multiple tissues with poorly understood kinetics. In this review, we provide an update on the dynamic distribution of neutrophils across tissues in health and disease, and emphasize differences between humans and model organisms. We further highlight issues to be addressed to exploit the unique features of neutrophils in the clinic.
eng
The Neutrophil Life Cycle
journal article
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URL
https://repisalud.isciii.es/bitstreams/f44148d3-578c-43ce-9446-9b26795ca50d/download
File
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TheNeutrophilLifeCycle_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/a47f4d3e-3465-4e32-8651-0ce9b81c7a13/download
File
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text/plain
TheNeutrophilLifeCycle_2019.pdf.txt