2026-06-14T03:29:48Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/97992025-04-22T12:02:31Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16939

00925njm 22002777a 4500 dc Ciruela, Pilar author Broner, Sonia author Izquierdo, Conchita author Pallarés, Román author Muñoz-Almagro, Carmen author Hernández, Sergi author Grau, Inmaculada author Domínguez, Angela author Jané, Mireia author The Catalan Working Group on Invasive Pneumococcal Disease author Fenoll, Asuncion author 2019-09 Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people ≥65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age ≥85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and ≥1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people ≥65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, ≥1 high-risk condition, and PCV13 serotypes. Int J Infect Dis. 2019 Sep;86:122-130. 10.1016/j.ijid.2019.06.030 1878-3511 1201-9712 International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 31283992 http://hdl.handle.net/20.500.12105/9799 Adults Case fatality rate Comorbidities IPD Mortality PCV13 Streptococcus pneumoniae Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults