2026-06-14T03:55:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/97902025-06-13T08:12:20Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Vilar, Marçal author Mira, Helena author 2016 The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in adult neurogenesis appear to be a common hallmark of different neurodegenerative diseases, understanding the molecular mechanisms controlling adult neurogenesis is a focus of active research. Neurotrophic factors are a family of molecules that play critical roles in the survival and differentiation of neurons during development and in the control of neural plasticity in the adult. Several neurotrophins and neurotrophin receptors have been implicated in the regulation of adult neurogenesis at different levels. Here, we review the current understanding of neurotrophin modulation of adult neurogenesis in both the SVZ and SGZ. We compile data supporting a variety of roles for neurotrophins/neurotrophin receptors in different scenarios, including both expected and unexpected functions. Front Neurosci. 2016 Feb 9;10:26. 10.3389/fnins.2016.00026 1662-4548 Frontiers in neuroscience 26903794 http://hdl.handle.net/20.500.12105/9790 BDNF NT3 TrkB Adult neurogenesis Neural stem cell Neurotrophin p75NTR Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles