2026-05-20T23:32:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/97322025-06-13T10:00:54Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19617
Repisalud
author
Pedro-Cuesta, Jesus de
author
Martínez-Martín, Pablo
author
Rábano, Alberto
author
Ruiz-Tovar, Maria
author
Alcalde-Cabero, Enrique
author
Calero, Miguel
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Instituto de Salud Carlos III
funder
Unión Europea
2020-04-24T07:18:03Z
2020-04-24T07:18:03Z
2016
Front Aging Neurosci. 2016 Jun 13;8:138.
10.3389/fnagi.2016.00138
1663-4365
Frontiers in aging neuroscience
27378910
http://hdl.handle.net/20.500.12105/9732
BACKGROUND: During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, sporadic, protein-associated, i.e., conformational, neurodegenerative disorders (NDDs), and their vascular- and metabolic-associated ailments. METHODS: A rationale is adopted, to incorporate selected clinical data and results from animal-model research, complementing epidemiologic evidences reported in two prior articles. FINDINGS: Theory is formulated assuming an underlying conformational transmission mechanism, mediated either by horizontal transfer of mammalian genes coding for specific aggregation-prone proteins, or by xeno-templating between bacterial and host proteins. We build a few population-based and experimentally-testable hypotheses focusing on: (1) non-disposable surgical instruments for sporadic Creutzfeldt-Jakob disease (sCJD) and other rapid progressive neurodegenerative dementia (sRPNDd), multiple system atrophy (MSA), and motor neuron disease (MND); and (2) specific bacterial infections such as B. pertussis and E. coli for all forms, but particularly for late-life sporadic conformational, NDDs, type 2 diabetes mellitus (T2DM), and atherosclerosis where natural protein fibrils present in such organisms as a result of adaptation to the human host induce prion-like mechanisms. CONCLUSION: Implications for cohort alignment and experimental animal research are discussed and research lines proposed.
eng
Disease induction vs. transmission in amyloid
Epidemiological patterns
Etiology of conformational protein deposits
Multidisciplinary research overlaps
Templating underlying risk/progression
Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
research article
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EtiologicFrameworkForThe_2016.pdf.txt