2026-07-05T14:52:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/97242025-05-30T09:15:43Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Piedrafita, Gabriel
author
Kostiou, Vasiliki
author
Wabik, Agnieszka
author
Colom, Bartomeu
author
Fernandez-Antoran, David
author
Herms, Albert
author
Murai, Kasumi
author
Hall, Benjamin A
author
Jones, Philip H
funder
Wellcome Trust
funder
Cancer Research UK (Reino Unido)
funder
Comunidad de Madrid (España)
2020-04-23T15:31:32Z
2020-04-23T15:31:32Z
2020-03-18
Nat Commun. 2020 ;11(1):1429.
10.1038/s41467-020-15258-0
2041-1723
2041-1723
Nature communications
32188860
http://hdl.handle.net/20.500.12105/9724
In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additional transgenic assay to follow cell division in mouse esophagus and the epidermis at multiple body sites. We find that proliferating cells divide at a similar rate, and place bounds on the distribution cell cycle times. By including these results in a common analytic approach, we show that data from eight lineage tracing experiments is consistent with tissue maintenance by a single population of proliferating cells. The outcome of a given cell division is unpredictable but, on average, the likelihood of producing proliferating and differentiating cells is equal, ensuring cellular homeostasis. These findings are key to understanding squamous epithelial homeostasis and carcinogenesis.
eng
STEM-CELL POPULATIONS
HAIR FOLLICLE
NTERFOLLICULAR EPIDERMIS
WOUND REPAIR
HOMEOSTASIS
IDENTIFICATION
COORDINATION
COMMITMENT
ORGANIZATION
COMPETITION
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
journal article
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Asingle-progenitormodel_2020.pdf.txt