2026-07-05T14:52:42Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/97242025-05-30T09:15:43Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Piedrafita, Gabriel author Kostiou, Vasiliki author Wabik, Agnieszka author Colom, Bartomeu author Fernandez-Antoran, David author Herms, Albert author Murai, Kasumi author Hall, Benjamin A author Jones, Philip H author 2020-03-18 In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additional transgenic assay to follow cell division in mouse esophagus and the epidermis at multiple body sites. We find that proliferating cells divide at a similar rate, and place bounds on the distribution cell cycle times. By including these results in a common analytic approach, we show that data from eight lineage tracing experiments is consistent with tissue maintenance by a single population of proliferating cells. The outcome of a given cell division is unpredictable but, on average, the likelihood of producing proliferating and differentiating cells is equal, ensuring cellular homeostasis. These findings are key to understanding squamous epithelial homeostasis and carcinogenesis. Nat Commun. 2020 ;11(1):1429. 10.1038/s41467-020-15258-0 2041-1723 2041-1723 Nature communications 32188860 http://hdl.handle.net/20.500.12105/9724 STEM-CELL POPULATIONS HAIR FOLLICLE NTERFOLLICULAR EPIDERMIS WOUND REPAIR HOMEOSTASIS IDENTIFICATION COORDINATION COMMITMENT ORGANIZATION COMPETITION A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice