2026-04-27T01:59:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/97222024-09-27T08:53:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Nicolas-Avila, Jose A.
author
Adrover, Jose M
author
Hidalgo, Andres
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Fundación ProCNIC
2020-04-23T14:34:54Z
2020-04-23T14:34:54Z
2017-01
Immunity. 2017; 46(1):15-28
1074-7613
http://hdl.handle.net/20.500.12105/9722
28099862
10.1016/j.immuni.2016.12.012
1097-4180
Immunity
Neutrophils were among the first leukocytes described and visualized by early immunologists. Prominent effector functions during infection and sterile inflammation classically placed them low in the immune tree as rapid, mindless aggressors with poor regulatory functions. This view is currently under reassessment as we uncover new aspects of their life cycle and identify transcriptional and phenotypic diversity that endows them with regulatory properties that extend beyond their lifetime in the circulation. These properties are revealing unanticipated roles for neutrophils in supporting homeostasis, as well as complex disease states such as cancer. We focus this review on these emerging functions in order to define the true roles of neutrophils in homeostasis, immunity, and disease.
eng
Neutrophils in Homeostasis, Immunity, and Cancer
journal article
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NeutrophilsHomeostasisImmunityCancer_2016.pdf
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NeutrophilsHomeostasisImmunityCancer_2016.pdf.txt