2026-06-14T03:42:46Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/96882024-09-27T08:21:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Martinez-Milla, Juan author Galan-Arriola, Carlos author Carnero, Manuel author Cobiella, Javier author Perez-Camargo, Daniel author Bautista-Hernandez, Victor author Rigol, Montserrat author Solanes, Nuria author Villena-Gutierrez, Rocio author Lobo-Gonzalez, Manuel author Mateo, Jesus author Vilchez, Jean Paul author Salinas, Beatriz author Cusso, Lorena author Lopez, Gonzalo Javier author Fuster, Valentin author Desco, Manuel author Sanchez-Gonzalez, Javier author Ibáñez, Borja author 2020-04-14 Nonrevascularizable coronary artery disease is a frequent cause of hibernating myocardium leading to heart failure (HF). Currently, there is a paucity of therapeutic options for patients with this condition. There is a lack of animal models resembling clinical features of hibernating myocardium. Here we present a large animal model of hibernating myocardium characterized by serial multimodality imaging. Yucatan minipigs underwent a surgical casein ameroid implant around the proximal left anterior descending coronary artery (LAD), resulting in a progressive obstruction of the vessel. Pigs underwent serial multimodality imaging including invasive coronary angiography, cardiac magnetic resonance (CMR), and hybrid 18F-Fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT). A total of 43 pigs were operated on and were followed for 120 ± 37 days with monthly multimodality imaging. 24 pigs (56%) died during the follow-up. Severe LAD luminal stenosis was documented in all survivors. In the group of 19 long-term survivors, 17 (90%) developed left ventricular systolic dysfunction [median LVEF of 35% (IQR 32.5-40.5%)]. In 17/17, at-risk territory was viable on CMR and 14 showed an increased glucose uptake in the at-risk myocardium on 18FDG-PET/CT. The present pig model resembles most of the human hibernated myocardium characteristics and associated heart failure (systolic dysfunction, viable myocardium, and metabolic switch to glucose). This human-like model might be used to test novel interventions for nonrevascularizable coronary artery disease and ischemia heart failure as a previous stage to clinical trials. Basic Res Cardiol. 2020; 115(3):33 10.1007/s00395-020-0788-0 1435-1803 Basic research in cardiology 32291522 http://hdl.handle.net/20.500.12105/9688 18FDG-PET/CT Cardiac magnetic resonance Dilated cardiomyopathy Heart failure Hibernating myocardium Large animal models Metabolic switch Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging