2026-07-22T03:36:56Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/96862025-05-27T10:46:27Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Calero, Miguel author Gómez-Ramos, Alberto author Calero, Olga author Soriano, Eduardo author Avila, Jesús author Medina, Miguel author 2015 Familial Alzheimer's disease (AD), mostly associated with early onset, is caused by mutations in three genes (APP, PSEN1, and PSEN2) involved in the production of the amyloid β peptide. In contrast, the molecular mechanisms that trigger the most common late onset sporadic AD remain largely unknown. With the implementation of an increasing number of case-control studies and the upcoming of large-scale genome-wide association studies there is a mounting list of genetic risk factors associated with common genetic variants that have been associated with sporadic AD. Besides apolipoprotein E, that presents a strong association with the disease (OR∼4), the rest of these genes have moderate or low degrees of association, with OR ranging from 0.88 to 1.23. Taking together, these genes may account only for a fraction of the attributable AD risk and therefore, rare variants and epistastic gene interactions should be taken into account in order to get the full picture of the genetic risks associated with AD. Here, we review recent whole-exome studies looking for rare variants, somatic brain mutations with a strong association to the disease, and several studies dealing with epistasis as additional mechanisms conferring genetic susceptibility to AD. Altogether, recent evidence underlines the importance of defining molecular and genetic pathways, and networks rather than the contribution of specific genes. Front Cell Neurosci. 2015 Apr 9;9:138. 10.3389/fncel.2015.00138 1662-5102 Frontiers in cellular neuroscience 25914626 http://hdl.handle.net/20.500.12105/9686 Alzheimer GWAS Epistasis Exome Neurodegeneration Rare variants Risk factors Somatic mutations Additional mechanisms conferring genetic susceptibility to Alzheimer's disease