2026-06-14T05:05:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/96702024-09-27T08:43:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
De Meyer, Tim
author
Nawrot, Tim
author
Bekaert, Sofie
author
De Buyzere, Marc L
author
Rietzschel, Ernst R
author
Andres, Vicente
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Fundación ProCNIC
2020-04-21T14:52:50Z
2020-04-21T14:52:50Z
2018-08
J Am Coll Cardiol. 2018; 72(7):805-813
10.1016/j.jacc.2018.06.014
1558-3597
0735-1097
Journal of the American College of Cardiology
30092957
http://hdl.handle.net/20.500.12105/9670
Telomeres shorten with age, the major risk factor for atherosclerotic cardiovascular disease (aCVD). The observation of shorter telomeres in aCVD patients thus suggested that critical telomere shortening may contribute to premature biological aging and aCVD. Therefore, telomere length often is suggested as a causal aCVD risk factor, a proposal supported by recent Mendelian randomization studies; however, epidemiological research has shown disappointingly low effect sizes. It therefore remains uncertain whether telomere shortening is a cause of aCVD or merely a consequence. The authors argue that elucidating the mechanistic foundation of these findings is essential for any possible translation of telomere biology to the clinic. Here, they critically evaluate evidence for causality in animal models and human studies, and review popular hypotheses and discuss their clinical implications. The authors identify 4 key questions that any successful mechanistic theory should address, and they discuss how atherosclerosis-associated local telomere attrition may provide the answers.
eng
atherosclerosis
biological aging
epidemiology
telomerase
Telomere Length as Cardiovascular Aging Biomarker: JACC Review Topic of the Week
journal article
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URL
https://repisalud.isciii.es/bitstreams/67c5c7f6-23b0-4114-b29e-a17830e6a48e/download
File
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application/pdf
TelomereLengthCardiovascularAging_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/dcb40e2e-3da3-49d5-aa2d-3fa77e8daeda/download
File
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text/plain
TelomereLengthCardiovascularAging_2018.pdf.txt