2026-06-30T03:57:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/96632024-09-27T08:26:40Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Baldan-Martin, Montserrat
author
Martin-Rojas, Tatiana
author
Corbacho-Alonso, Nerea
author
Lopez, Juan Antonio
author
Sastre-Oliva, Tamara
author
Gil-Dones, Felix
author
Vazquez, Jesus
author
Arevalo, Jose Manuel
author
Mourino-Alvarez, Laura
author
Barderas, Maria G
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Sociedad Española de Cardiología
2020-04-21T13:29:31Z
2020-04-21T13:29:31Z
2020-05
Adv Wound Care. 2020; 9(5):277-294
10.1089/wound.2019.0968
2162-1918
Advances in wound care
32226651
http://hdl.handle.net/20.500.12105/9663
Objective: Severe pressure ulcers (PUs) do not respond to conservative wound therapy and need surgical repair. To better understand the pathogenesis and to advance on new therapeutic options, we focused on the proteomic analysis of PU, which offers substantial opportunities to identify significant changes in protein abundance during the course of PU formation in an unbiased manner. Approach: To better define the protein pattern of this pathology, we performed a proteomic approach in which we compare severe PU tissue from spinal cord injury (SCI) patients with control tissue from the same patients. Results: We found 76 proteins with difference in abundance. Of these, 10 proteins were verified as proteins that define the pathology: antithrombin-III, alpha-1-antitrypsin, kininogen-1, alpha-2-macroglobulin, fibronectin, apolipoprotein A-I, collagen alpha-1 (XII) chain, haptoglobin, apolipoprotein B-100, and complement factor B. Innovation: This is the first study to analyze differential abundance protein of PU tissue from SCI patients using high-throughput protein identification and quantification by tandem mass tags followed by liquid chromatography tandem mass spectrometry. Conclusion: Differential abundance proteins are mainly involved in tissue regeneration. These proteins might be considered as future therapeutic options to enhance the physiological response and permit cellular repair of damaged tissue.
eng
Pressure ulcer
Proteomics
Spinal cord injury
Tandem mass tags
Comprehensive Proteomic Profiling of Pressure Ulcers in Patients with Spinal Cord Injury Identifies a Specific Protein Pattern of Pathology
journal article
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URL
https://repisalud.isciii.es/bitstreams/052af036-bdb2-46ec-9f11-58d0d291f97e/download
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3d0277a6b946035f6c46cc1ebd2a5cd7
2021928
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ComprehensiveProteomicProfilingPressure_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/41469e87-8db6-4766-9e55-9a3814f76d70/download
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text/plain
ComprehensiveProteomicProfilingPressure_2020.pdf.txt