2026-07-21T21:47:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/96322024-10-31T11:45:07Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Casanova-Acebes, Maria author Menendez-Gutierrez, Maria Piedad author Porcuna, Jesus author Alvarez-Errico, Damiana author Lavin, Yonit author Garcia, Ana author Kobayashi, Soma author Le Berichel, Jessica author Nunez, Vanessa author Were, Felipe author Jimenez-Carretero, Daniel author Sanchez-Cabo, Fatima author Merad, Miriam author Ricote, Mercedes author 2020-04-03 Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility and the transcriptional regulation of canonical macrophage genes. RXR deficiency impairs neonatal expansion of the LPM pool and reduces the survival of adult LPMs through excess lipid accumulation. We also find that peritoneal LPMs infiltrate early ovarian tumours and that RXR deletion diminishes LPM accumulation in tumours and strongly reduces ovarian tumour progression in mice. Our study reveals that RXR signalling controls the maintenance of the serous macrophage pool and that targeting peritoneal LPMs may improve ovarian cancer outcomes. Nat Commun. 2020; 11(1):1655 10.1038/s41467-020-15371-0 2041-1723 2041-1723 Nature communications 32246014 http://hdl.handle.net/20.500.12105/9632 RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression