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00925njm 22002777a 4500 dc del Fresno, Carlos author Sancho, David author 2020-01 Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. Immunity. 2020; 52(1):6-8 10.1016/j.immuni.2019.12.015 1097-4180 1074-7613 Immunity 31951550 http://hdl.handle.net/20.500.12105/9619 Clec2d Joins the Cell Death Sensor Ranks