2026-05-10T14:28:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/96182024-09-27T08:03:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Wculek, Stefanie K
author
Cueto, Francisco J.
author
Mujal, Adriana M
author
Melero, Ignacio
author
Krummel, Matthew F
author
Sancho, David
funder
European Molecular Biology Organization
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Atresmedia
funder
Fundación La Marató TV3
funder
Fundación ProCNIC
2020-04-20T07:14:23Z
2020-04-20T07:14:23Z
2020-01
Nat Rev Immunol. 2020; 20(1):7-24
10.1038/s41577-019-0210-z
1474-1741
1474-1733
Nature reviews. Immunology
31467405
http://hdl.handle.net/20.500.12105/9618
Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve cancer immunotherapy. Many strategies have been developed to target DCs in cancer, such as the administration of antigens with immunomodulators that mobilize and activate endogenous DCs, as well as the generation of DC-based vaccines. A better understanding of the diversity and functions of DC subsets and of how these are shaped by the tumour microenvironment could lead to improved therapies for cancer. Here we will outline how different DC subsets influence immunity and tolerance in cancer settings and discuss the implications for both established cancer treatments and novel immunotherapy strategies.
eng
Dendritic cells in cancer immunology and immunotherapy
journal article
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URL
https://repisalud.isciii.es/bitstreams/2a369590-ad78-4177-b07c-95e86716e16e/download
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DendriticCellsCancerImmunology_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/29a0a038-0019-4ef7-9b3f-d066bdd7d739/download
File
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DendriticCellsCancerImmunology_2020.pdf.txt