2026-04-29T04:09:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/95922025-06-17T10:29:43Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Cidre-Aranaz, Florencia
author
Alonso, Javier
funder
Instituto de Salud Carlos III
2020-04-16T13:13:11Z
2020-04-16T13:13:11Z
2015
Front Oncol. 2015 Jul 20;5:162.
2234-943X
http://hdl.handle.net/20.500.12105/9592
26258070
10.3389/fonc.2015.00162
Frontiers in oncology
Ewing sarcoma is an aggressive bone malignancy that affect children and young adults. Ewing sarcoma is the second most common primary bone malignancy in pediatric patients. Although significant progress has been made in the treatment of Ewing sarcoma since it was first described in the 1920s, in the last decade survival rates have remained unacceptably invariable, thus pointing to the need for new approaches centered in the molecular basis of the disease. Ewing sarcoma driving mutation, EWS-FLI1, which results from a chromosomal translocation, encodes an aberrant transcription factor. Since its first characterization in 1990s, many molecular targets have been described to be regulated by this chimeric transcription factor. Their contribution to orchestrate Ewing sarcoma phenotype has been reported over the last decades. In this work, we will focus on the description of a selection of EWS/FLI1 targets, their functional role, and their potential clinical relevance. We will also discuss their role in other types of cancer as well as the need for further studies to be performed in order to achieve a broader understanding of their particular contribution to Ewing sarcoma development.
eng
CCK
DAX-1
EWS/FLI1
Ewing sarcoma
FOXM1
FOXO1
GLI1
LOX
EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
research article
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URL
https://repisalud.isciii.es/bitstreams/1020ccee-d8e9-4923-8aab-547fe9ca4efa/download
File
MD5
ed4eb22739350ea634440728c52d19f6
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application/pdf
EWSFLI1TargetGenes_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/30321ccb-49f6-4634-8ef9-20014cbedd3c/download
File
MD5
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text/plain
EWSFLI1TargetGenes_2015.pdf.txt