2026-06-14T03:30:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/95322025-05-27T13:33:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Gonzalez-Gomez, Pilar
author
Anselmo, Nilson Praia
author
Mira, Helena
funder
Comunidad de Madrid (España)
funder
Fundación Pedro Barrié de la Maza
2020-04-13T12:47:51Z
2020-04-13T12:47:51Z
2014
Biomed Res Int. 2014;2014:549742.
10.1155/2014/549742
2314-6141
2314-6133
BioMed research international
24877113
http://hdl.handle.net/20.500.12105/9532
Astrocytic glioma is the most common brain tumor. The glioma initiating cell (GIC) fraction of the tumor is considered as highly chemoresistant, suggesting that GICs are responsible for glioma relapse. A potential treatment for glioma is to induce differentiation of GICs to a more benign and/or druggable cell type. Given BMPs are among the most potent inducers of GIC differentiation, they have been considered as noncytotoxic therapeutic compounds that may be of use to prevent growth and recurrence of glioma. We herein summarize advances made in the understanding of the role of BMP signaling in astrocytic glioma, with a particular emphasis on the effects exerted on GICs. We discuss the prognostic value of BMP signaling components and the implications of BMPs in the differentiation of GICs and in their sensitization to alkylating drugs and oncolytic therapy/chemotherapy. This mechanistic insight may provide new opportunities for therapeutic intervention of brain cancer.
eng
BMPs as therapeutic targets and biomarkers in astrocytic glioma
research article
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URL
https://repisalud.isciii.es/bitstreams/08dd93a3-355e-4021-8928-b8930304e605/download
File
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application/pdf
BMPsAsTherapeuticTargets_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/c845f367-c2fd-4de5-a414-e2a065c30f44/download
File
MD5
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text/plain
BMPsAsTherapeuticTargets_2014.pdf.txt