2026-06-14T03:33:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/95062024-09-27T09:43:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rossello, Xavier
author
Piñero, Antonio
author
Fernandez-Jimenez, Rodrigo
author
Sanchez-Gonzalez, Javier
author
Pizarro, Gonzalo
author
Galan-Arriola, Carlos
author
Lobo-Gonzalez, Manuel
author
Vilchez, Jean Paul
author
Garcia-Prieto, Jaime
author
Garcia-Ruiz, Jose M
author
Garcia-Alvarez, Ana
author
Sanz-Rosa, David
author
Ibáñez, Borja
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Sociedad Española de Cardiología
funder
Unión Europea. Comisión Europea
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2020-04-13T08:58:03Z
2020-04-13T08:58:03Z
2018-08
J Cardiovasc Transl Res. 2018; 11(4):310-318
10.1007/s12265-018-9819-8
1937-5395
1937-5387
Journal of cardiovascular translational research
30073540
http://hdl.handle.net/20.500.12105/9506
The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use. A dose-response study was conducted in 6 pigs to select the highest intravenous dose of mirabegron without significant detrimental hemodynamic effect. Subsequently, closed chest anterior myocardial infarction (45 min ischemia followed by reperfusion) was performed in 26 pigs which randomly received either mirabegron (10 μg/kg) or placebo 5 min before reperfusion. Day-7 cardiac magnetic resonance (CMR) showed no differences in infarct size (35.0 ± 2.0% of left ventricle (LV) vs. 35.9 ± 2.4% in mirabegron and placebo respectively, p = 0.782) or LV ejection fraction (36.3 ± 1.1 vs. 34.6 ± 1.9%, p = 0.430). Consistent results were obtained on day-45 CMR. In conclusion, the intravenous administration of the clinically available selective β3AR agonist mirabegron does not reduce infarct size in a swine model of IRI.
eng
Acute myocardial infarction
Cardioprotection
Ischemia/reperfusion injury
Mirabegron
Translational models
β3 adrenergic receptor
Mirabegron, a Clinically Approved β3 Adrenergic Receptor Agonist, Does Not Reduce Infarct Size in a Swine Model of Reperfused Myocardial Infarction
journal article
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MirabegronClinicallyApprovedBeta3_2018.pdf
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text/plain
MirabegronClinicallyApprovedBeta3_2018.pdf.txt