2026-08-12T20:37:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/94832024-09-27T09:26:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rossello, Xavier
author
Lobo-Gonzalez, Manuel
author
Ibáñez, Borja
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Sociedad Española de Cardiología
2020-04-08T11:28:27Z
2020-04-08T11:28:27Z
2019-08
Eur Heart J Acute Cardiovasc Care. 2019; 8(5):443-56
10.1177/2048872619845283
2048-8734
2048-8726
European heart journal. Acute cardiovascular care
31172789
http://hdl.handle.net/20.500.12105/9483
There is a need to find interventions able to reduce the extent of injury in reperfused ST-segment elevation myocardial infarction (STEMI) beyond timely reperfusion. In this review, we summarise the clinical impact of STEMI from epidemiological, clinical and biological perspectives. We also revise the pathophysiology underlying the ischaemia/reperfusion syndrome occurring in reperfused STEMI, including the several players involved in this syndrome, such as cardiomyocytes, microcirculation and circulating cells. Interventions aimed to reduce the resultant infarct size, known as cardioprotective therapies, are extensively discussed, putting the focus on both mechanical interventions (i.e. ischaemic conditioning) and promising pharmacological therapies, such as early intravenous metoprolol, exenatide and other glucose modulators, N-acetylcysteine as well as on some other classic therapies which have failed to be translated to the clinical arena. Novel targets for evolving therapeutic interventions to ameliorate ischaemia/reperfusion injury are also discussed. Finally, we highlight the necessity to improve the study design of future randomised clinical trials in the field, as well as to select patients better who can most likely benefit from cardioprotective interventions.
eng
Ischaemia/reperfusion injury
Acute myocardial infarction
Cardioprotection
Editor's Choice- Pathophysiology and therapy of myocardial ischaemia/reperfusion syndrome
journal article
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URL
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File
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PathophysiologyTherapyMyocardialIschaemia_2019.pdf
URL
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File
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PathophysiologyTherapyMyocardialIschaemia_2019.pdf.txt