2026-06-14T03:28:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/94492024-11-29T09:17:29Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16973
Repisalud
author
Tarancón, Raquel
author
Domínguez-Andrés, Jorge
author
Uranga, Santiago
author
Ferreira, Anaísa V
author
Groh, Laszlo A
author
Domenech Lucas, Mirian
author
Gonzalez-Camacho, Fernando
author
Riksen, Niels P
author
Aguilo, Nacho
author
Yuste, Jose Enrique
author
Martín, Carlos
author
Netea, Mihai G
funder
Dutch Research Council (Holanda)
funder
Ministerio de Ciencia y Universidades (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2020-04-07T07:40:54Z
2020-04-07T07:40:54Z
2020-04
PLoS Pathog. 2020 Apr 2;16(4):e1008404
10.1371/journal.ppat.1008404
1553-7374
1553-7374
PLoS pathogens
32240273
http://hdl.handle.net/20.500.12105/9449
Among infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus Calmette-Guerin (BCG), the current vaccine against tuberculosis, have been related not only to specific induction of T-cell immunity, but also with the long-term epigenetic and metabolic reprogramming of the cells from the innate immune system through a process termed trained immunity. Here we show that MTBVAC, a live attenuated strain of Mycobacterium tuberculosis, safe and immunogenic against tuberculosis antigens in adults and newborns, is also able to generate trained immunity through the induction of glycolysis and glutaminolysis and the accumulation of histone methylation marks at the promoters of proinflammatory genes, facilitating an enhanced response after secondary challenge with non-related bacterial stimuli. Importantly, these findings in human primary myeloid cells are complemented by a strong MTBVAC-induced heterologous protection against a lethal challenge with Streptococcus pneumoniae in an experimental murine model of pneumonia.
eng
New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia
journal article
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URL
https://repisalud.isciii.es/bitstreams/6a8084d3-d58d-4ad4-aaa4-971ce61e7165/download
File
MD5
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application/pdf
NewLiveAttenuatedTuberculosis_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/357a0bc9-b77e-4424-8241-d6d10a31a019/download
File
MD5
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text/plain
NewLiveAttenuatedTuberculosis_2020.pdf.txt