2026-06-14T03:37:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/94422024-09-27T08:51:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cortes-Canteli, Marta
author
Iadecola, Costantino
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
National Institutes of Health (Estados Unidos)
2020-04-03T11:59:13Z
2020-04-03T11:59:13Z
2020-03-03
J Am Coll Cardiol. 2020; 75(8):942-951
10.1016/j.jacc.2019.10.062
1558-3597
07351097
Journal of the American College of Cardiology
32130930
http://hdl.handle.net/20.500.12105/9442
Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibility that they may have a pathogenic role. This review provides an appraisal of the alterations in cerebral and systemic vasculature, the heart, and hemostasis that occur in Alzheimer's disease and their relationships to cognitive impairment. Although the molecular pathogenesis of these alterations remains to be defined, amyloid-β is a likely contributor in the brain as in the heart. Collectively, the evidence suggests that vascular pathology is a likely pathogenic contributor to age-related dementia, including Alzheimer's disease, inextricably linked to disease onset and progression. Consequently, the contribution of vascular factors should be considered in preventive, diagnostic, and therapeutic approaches to address one of the major health challenges of our time.
eng
Atherosclerosis
Blood-brain barrier
Cerebral blood flow
Dementia
Hypertension
Vascular dysfunction
Alzheimer's Disease and Vascular Aging: JACC Focus Seminar
journal article
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AlzheimerDiseaseVascularAging_2020.pdf
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AlzheimerDiseaseVascularAging_2020.pdf.txt