2026-04-29T07:22:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/93732024-11-29T21:07:35Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Grazioso, Tatiana P
author
Brandt, Marta
author
Djouder, Nabil
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-03-30T15:10:26Z
2020-03-30T15:10:26Z
2019-11-22
iScience. 2019 ;21:168-187.
25890042
http://hdl.handle.net/20.500.12105/9373
31669832
10.1016/j.isci.2019.10.011
2589-0042
iScience
The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells.
eng
Biological Sciences
Cancer
Microbiome
Diet, Microbiota, and Colorectal Cancer
journal article
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URL
https://repisalud.isciii.es/bitstreams/2662780f-a211-44f8-8798-42496f49a801/download
File
MD5
53537b9e74ae166ded8fb15ca60f8428
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application/pdf
InstrumentedMicrophysiologicalSystems_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/0f2bb8b0-09fb-496e-9775-3947115bde78/download
File
MD5
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text/plain
InstrumentedMicrophysiologicalSystems_2019.pdf.txt