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oai:repisalud.isciii.es:20.500.12105/93732024-11-29T21:07:35Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Grazioso, Tatiana P author Brandt, Marta author Djouder, Nabil author 2019-11-22 The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells. iScience. 2019 ;21:168-187. 25890042 http://hdl.handle.net/20.500.12105/9373 31669832 10.1016/j.isci.2019.10.011 2589-0042 iScience Biological Sciences Cancer Microbiome Diet, Microbiota, and Colorectal Cancer