2026-06-14T06:44:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/93672024-09-27T09:12:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hamczyk, Magda R.
author
Nevado, Rosa M
author
Barettino, Ana
author
Fuster, Valentin
author
Andres, Vicente
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
Fundación La Marató TV3
2020-03-30T13:44:24Z
2020-03-30T13:44:24Z
2020-03-03
J Am Coll Cardiol. 2020; 75(8):919-930
10.1016/j.jacc.2019.11.062
1558-3597
07351097
Journal of the American College of Cardiology
32130928
http://hdl.handle.net/20.500.12105/9367
Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.
eng
Antiaging therapy
Biological age
Biological age biomarkers
Chronological age
Vascular disease
Biological Versus Chronological Aging: JACC Focus Seminar
journal article
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BiologicalVersusChronologicalAging_2020.pdf
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BiologicalVersusChronologicalAging_2020.pdf.txt