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00925njm 22002777a 4500 dc Carril-Ajuria, Lucía author Santos, María author Roldán-Romero, Juan María author Rodriguez Antona, Cristina author de Velasco, Guillermo author 2019-12-19 Renal cell carcinoma (RCC) is the most frequent kidney solid tumor, the clear cell RCC (ccRCC) being the major histological subtype. The probability of recurrence and the clinical behavior of ccRCC will greatly depend on the different clinical and histopathological features, already incorporated to different scoring systems, and on the genomic landscape of the tumor. In this sense, ccRCC has for a long time been known to be associated to the biallelic inactivation of Von Hippel-Lindau (VHL) gene which causes aberrant hypoxia inducible factor (HIF) accumulation. Recently, next generation-sequencing technologies have provided the bases for an in-depth molecular characterization of ccRCC, identifying additional recurrently mutated genes, such as PBRM1 (≈40-50%), SETD2 (≈12%), or BAP1 (≈10%). PBRM1, the second most common mutated gene in ccRCC after VHL, is a component of the SWI/SNF chromatin remodeling complex. Different studies have investigated the biological consequences and the potential role of PBRM1 alterations in RCC prognosis and as a drug response modulator, although some results are contradictory. In the present article, we review the current evidence on PBRM1 as potential prognostic and predictive marker in both localized and metastatic RCC. Cancers (Basel). 2019 ;12(1). 10.3390/cancers12010016 2072-6694 Cancers 31861590 http://hdl.handle.net/20.500.12105/9342 PBRM1 biomarker polybromo-1 predictive role prognosis renal cell carcinoma Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma