2026-06-14T05:06:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/93272024-10-31T11:39:39Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Marín-Aguilar, Fabiola
author
Lechuga-Vieco, Ana V.
author
Alcocer-Gómez, Elísabet
author
Castejón-Vega, Beatriz
author
Lucas, Javier
author
Garrido, Carlos
author
Peralta-Garcia, Alejandro
author
Pérez-Pulido, Antonio J
author
Varela-López, Alfonso
author
Quiles, José L
author
Ryffel, Bernhard
author
Flores, Ignacio
author
Bullón, Pedro
author
Ruiz-Cabello, Jesus
author
Cordero, Mario D
funder
Regional Government of Andalusia (España)
funder
Ministerio de Economía y Competitividad (España)
2020-03-25T11:56:36Z
2020-03-25T11:56:36Z
2020-01
Aging Cell. 2020; 19(1):e13050
10.1111/acel.13050
1474-9726
1474-9718
Aging cell
31625260
http://hdl.handle.net/20.500.12105/9327
While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inflammation. Here, we investigated the molecular mechanisms through which NLRP3 inhibition may attenuate cardiac aging. Ablation of NLRP3-inflammasome protected mice from age-related increased insulin sensitivity, reduced IGF-1 and leptin/adiponectin ratio levels, and reduced cardiac damage with protection of the prolongation of the age-dependent PR interval, which is associated with atrial fibrillation by cardiovascular aging and reduced telomere shortening. Furthermore, old NLRP3 KO mice showed an inhibition of the PI3K/AKT/mTOR pathway and autophagy improvement, compared with old wild mice and preserved Nampt-mediated NAD+ levels with increased SIRT1 protein expression. These findings suggest that suppression of NLRP3 prevented many age-associated changes in the heart, preserved cardiac function of aged mice and increased lifespan.
eng
NLRP3-inflammasome
Autophagy
Cardiac aging
Longevity
Morbidity
Mortality
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
journal article
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