2026-06-14T03:52:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/93202024-11-29T23:04:35Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Gago-Lopez, Nuria author Mellor Liliana, Mellor Liliana F author Megias Vazquez, Diego author Martín-Serrano, Guillermo author Izeta, Ander author Jimenez, Francisco author Wagner, Erwin Friedrich author 2019-11-07 Psoriasis is a common inflammatory skin disease involving a cross-talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF-SCs) in psoriasis is not well defined. Here, we show reduced expression of c-JUN and JUNB in bulge HF-SCs in patients with scalp psoriasis. Using lineage tracing in mouse models of skin inflammation with inducible deletion of c-Jun and JunB, we found that mutant bulge HF-SCs initiate epidermal hyperplasia and skin inflammation. Mechanistically, thymic stromal lymphopoietin (TSLP) was identified in mutant cells as a paracrine factor stimulating proliferation of neighboring non-mutant epidermal cells, while mutant inter-follicular epidermal (IFE) cells are lost over time. Blocking TSLP in psoriasis-like mice reduced skin inflammation and decreased epidermal proliferation, VEGFα expression, and STAT5 activation. These findings unravel distinct roles of HF-SCs and IFE cells in inflammatory skin disease and provide novel mechanistic insights into epidermal cell interactions in inflammation. EMBO Mol Med. 2019;11(11):e10697. 10.15252/emmm.201910697 1757-4684 1757-4676 EMBO molecular medicine 31556482 http://hdl.handle.net/20.500.12105/9320 Epidermal hyper-proliferation Hair follicle stem cells Lineage tracing Psoriasis Thymic stromal lymphopoietin Role of bulge epidermal stem cells and TSLP signaling in psoriasis