2026-06-14T03:32:18Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/93082024-11-29T08:28:19Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16968col_20.500.12105_16972

00925njm 22002777a 4500 dc Pagonabarraga, Javier author Arbelo, José Matías author Grandas, Francisco author Luquin, Maria-Rosario author Martínez-Martín, Pablo author Rodríguez-Oroz, Mari Cruz author Valldeoriola, Francesc author Kulisevsky, Jaime author 2020-03-18 Safinamide is an approved drug for the treatment of motor fluctuations in Parkinson's disease (PD). Scarce data are available on its use in clinical practice. A group of Spanish movement disorders specialists was convened to review the use of safinamide across different clinical scenarios that may guide neurologists in clinical practice. Eight specialists with recognized expertise in PD management elaborated the statements based on available evidence in the literature and on their clinical experience. The RAND/UCLA method was carried, with final conclusions accepted after a 2-round modified Delphi process. Higher level of agreement between panellists was reached for the following statements. Safinamide significantly improves mean daily OFF time without troublesome dyskinesias. Adjunctive treatment with safinamide is associated with motor improvements in patients with mid-to-late PD. The efficacy of safinamide on motor fluctuations is maintained at long-term, with no increase over time in dyskinesias severity. The clinical benefits of safinamide on pain and depression remain unclear. Safinamide presents a similar incidence of adverse events compared with placebo. The efficacy and safety of safinamide shown in the pivotal clinical trials are reproduced in clinical practice, with improvement of parkinsonian symptoms, decrease of daily OFF time, control of dyskinesias at the long term, and good tolerability and safety. Brain Sci. 2020 Mar 18;10(3):E176. 10.3390/brainsci10030176 2076-3425 Brain sciences 32197462 http://hdl.handle.net/20.500.12105/9308 RAND/UCLA appropriateness method Dyskinesia Efficacy Fluctuations Safety Safinamide A Spanish Consensus on the Use of Safinamide for Parkinson's Disease in Clinical Practice