2026-04-29T04:00:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/92472024-10-31T11:58:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Santos-Lozano, Alejandro
author
Valenzuela, Pedro L
author
Llavero, Francisco
author
Lista, Simone
author
Carrera-Bastos, Pedro
author
Hampel, Harald
author
Pareja-Galeano, Helios
author
Gálvez, Beatriz G
author
Lopez, Juan Antonio
author
Vazquez, Jesus
author
Emanuele, Enzo
author
Zugaza, José L
author
Lucia, Alejandro
funder
University of Alcalá (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación La Marató TV3
funder
Fundación La Caixa
funder
Fundación ProCNIC
funder
Fundación AXA
funder
Fundación de la Universidad Europea de Madrid
2020-03-09T13:48:34Z
2020-03-09T13:48:34Z
2020-02
Aging (Albany NY). 2020; 12(4):3502-3515
1945-4589
http://hdl.handle.net/20.500.12105/9247
32100723
10.18632/aging.102826
1945-4589
Aging
Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.
eng
Elderly
Healthy aging
Immune system
Proteomics
Senescence
Successful aging: insights from proteome analyses of healthy centenarians
journal article
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