2026-04-29T04:00:31Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/92472024-10-31T11:58:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Santos-Lozano, Alejandro author Valenzuela, Pedro L author Llavero, Francisco author Lista, Simone author Carrera-Bastos, Pedro author Hampel, Harald author Pareja-Galeano, Helios author Gálvez, Beatriz G author Lopez, Juan Antonio author Vazquez, Jesus author Emanuele, Enzo author Zugaza, José L author Lucia, Alejandro author 2020-02 Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging. Aging (Albany NY). 2020; 12(4):3502-3515 1945-4589 http://hdl.handle.net/20.500.12105/9247 32100723 10.18632/aging.102826 1945-4589 Aging Elderly Healthy aging Immune system Proteomics Senescence Successful aging: insights from proteome analyses of healthy centenarians