2026-06-14T03:29:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91652025-06-13T09:58:20Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Cordero, Joaquín G
author
García-Escudero, Ramón
author
Avila, Jesús
author
Gargini, Ricardo
author
García-Escudero, Vega
funder
Ministerio de Economía y Competitividad (España)
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Asociación Española Contra el Cáncer
2020-03-02T12:10:51Z
2020-03-02T12:10:51Z
2018
Oxid Med Cell Longev. 2018 Feb 20;2018:5010741.
10.1155/2018/5010741
1942-0994
1942-0900
Oxidative medicine and cellular longevity
29675133
http://hdl.handle.net/20.500.12105/9165
Alzheimer's disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β-amyloid. Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion. Autophagy deficiency has been demonstrated in Alzheimer's patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress. In the present study, we demonstrated by microarray analysis the downregulation of fundamental autophagy and mitophagy pathways in Alzheimer's patients. The benefits of the Mediterranean diet on Alzheimer's disease and cognitive impairment are well known, attributing this effect to several polyphenols, such as oleuropein aglycone (OLE), present in extra virgin olive oil. OLE is able to induce autophagy, achieving a decrease of aggregated proteins and a reduction of cognitive impairment in vivo. This effect is caused by the modulation of several pathways including the AMPK/mTOR axis and the activation of autophagy gene expression mediated by sirtuins and histone acetylation or EB transcription factor. We propose that supplementation of diet with extra virgin olive oil might have potential benefits for Alzheimer's patients by the induction of autophagy by OLE.
eng
Benefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagy
research article
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URL
https://repisalud.isciii.es/bitstreams/a65220e9-9078-44e1-97b6-3eeb87dab256/download
File
MD5
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application/pdf
BenefitOfOleuropeinAglycone_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/480350c7-fbe9-482d-9ed8-60a2e2b45f08/download
File
MD5
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text/plain
BenefitOfOleuropeinAglycone_2018.pdf.txt