2026-08-29T14:04:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91632025-05-05T10:38:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Hernandez-SanMiguel, Esther
author
Gargini, Ricardo
author
Cejalvo, Teresa
author
Segura-Collar, Berta
author
Nuñez-Hervada, Paula
author
Hortigüela, Rafael
author
Sepúlveda-Sánchez, Juan Manuel
author
Hernández-Laín, Aurelio
author
Pérez-Núñez, Ángel
author
Sanz, Eduardo
author
Sánchez-Gómez, Pilar
funder
Asociación Española Contra el Cáncer
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
funder
Ministerio de Economía y Competitividad (España)
2020-03-02T09:54:32Z
2020-03-02T09:54:32Z
2019
Oxid Med Cell Longev. 2019 Aug 5;2019:9719730.
10.1155/2019/9719730
1942-0994
1942-0900
Oxidative medicine and cellular longevity
31467641
http://hdl.handle.net/20.500.12105/9163
Glioblastoma (GBM) is the most common and devastating primary brain tumor. The presence of cancer stem cells (CSCs) has been linked to their therapy resistance. Molecular and cellular components of the tumor microenvironment also play a fundamental role in the aggressiveness of these tumors. In particular, high levels of hypoxia and reactive oxygen species participate in several aspects of GBM biology. Moreover, GBM contains a large number of macrophages, which normally behave as immunosuppressive tumor-supportive cells. In fact, the presence of both, hypoxia and M2-like macrophages, correlates with malignancy and poor prognosis in gliomas. Antioxidant agents, as nutritional supplements, might have antitumor activity. Ocoxin® oral solution (OOS), in particular, has anti-inflammatory and antioxidant properties, as well as antitumor properties in several neoplasia, without known side effects. Here, we describe how OOS affects stem cell properties in certain GBMs, slowing down their tumor growth. In parallel, OOS has a direct effect on macrophage polarization in vitro and in vivo, inhibiting the protumoral features of M2 macrophages. Therefore, OOS could be a feasible candidate to be used in combination therapies during GBM treatment because it can target the highly resilient CSCs as well as their supportive immune microenvironment, without adding toxicity to conventional treatments.
eng
Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma
research article
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URL
https://repisalud.isciii.es/bitstreams/58fccb75-d237-4a1c-af2e-48e4b1546ed2/download
File
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application/pdf
OcoxinModulatesCancerStem_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/ffaba901-dd7c-476f-92db-fe995ba6c853/download
File
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text/plain
OcoxinModulatesCancerStem_2019.pdf.txt