2026-06-14T03:29:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91542025-04-01T10:57:29Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16964col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16975col_20.500.12105_16981col_20.500.12105_16983
Repisalud
author
Ibáñez-Sanz, Gemma
author
Díez-Villanueva, Anna
author
Vilorio-Marqués, Laura
author
Gracia, Esther
author
Aragones, Nuria
author
Olmedo-Requena, Rocío
author
Llorca, Javier
author
Vidán, Juana
author
Amiano, Pilar
author
Nos, Pilar
author
Fernández-Tardón, Guillermo
author
Rada, Ricardo
author
Chirlaque, María-Dolores
author
Guinó, Elisabet
author
Dávila-Batista, Verónica
author
Castaño-Vinyals, Gemma
author
Perez-Gomez, Beatriz
author
Mirón-Pozo, Benito
author
Dierssen-Sotos, Trinidad
author
Etxeberria, Jaione
author
Molinuevo, Amaia
author
Álvarez-Cuenllas, Begoña
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Moreno, Victor
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Marqués de Valdecilla
funder
Junta de Castilla y León (España)
funder
Regional Government of Andalusia (España)
funder
Generalitat Valenciana (España)
funder
Fundación La Caixa
funder
Basque Government (España)
funder
Gobierno de la Región de Murcia (España)
funder
Unión Europea. Comisión Europea
funder
Asociación Española Contra el Cáncer
funder
Government of Catalonia (España)
funder
Fundación Cajastur
funder
University of Oviedo (España)
2020-02-28T07:57:58Z
2020-02-28T07:57:58Z
2018
Sci Rep. 2018 Feb 1;8(1):2040.
10.1038/s41598-018-20349-6
2045-2322
2045-2322
Scientific reports
29391578
http://hdl.handle.net/20.500.12105/9154
A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28-0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47-1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62-0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs.
eng
Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study
research article
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PossibleRoleOfChondroitin_2018.pdf
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PossibleRoleOfChondroitin_2018.pdf.txt