2026-06-14T13:27:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91462025-06-12T13:49:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19611
Repisalud
author
Martin-Alonso, Aarón
author
Cohen, Amy
author
Quispe-Ricalde, María Antonieta
author
Foronda, Pilar
author
Benito, Agustin
author
Berzosa, Pedro
author
Valladares, Basilio
author
Grau, Georges E
funder
National Health and Medical Research Council (Australia)
2020-02-25T12:12:13Z
2020-02-25T12:12:13Z
2018
Sci Rep. 2018 Jul 26;8(1):11277.
10.1038/s41598-018-29721-y
2045-2322
2045-2322
Scientific reports
30050092
http://hdl.handle.net/20.500.12105/9146
Cerebral malaria (CM) is the most severe manifestation of infection with Plasmodium, however its pathogenesis is still not completely understood. microRNA (miRNA) have been an area of focus in infectious disease research, due to their ability to affect normal biological processes, and have been shown to play roles in various viral, bacterial and parasitic infections, including malaria. The expression of miRNA was studied following infection of CBA mice with either Plasmodium berghei ANKA (causing CM), or Plasmodium yoelii (causing severe but non-cerebral malaria (NCM)). Using microarray analysis, miRNA expression was compared in the brains of non-infected (NI), NCM and CM mice. Six miRNA were significantly dysregulated between NCM and CM mice, and four of these, miR-19a-3p, miR-19b-3p, miR-142-3p and miR-223-3p, were further validated by qPCR assays. These miRNA are significantly involved in several pathways relevant to CM, including the TGF-β and endocytosis pathways. Dysregulation of these miRNA during CM specifically compared with NCM suggests that these miRNA, through their regulation of downstream targets, may be vitally involved in the neurological syndrome. Our data implies that, at least in the mouse model, miRNA may play a regulatory role in CM pathogenesis.
eng
Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-β signalling pathways
research article
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DifferentiallyExpressedMicroRNAsIn_2018.pdf
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DifferentiallyExpressedMicroRNAsIn_2018.pdf.txt