2026-07-21T14:20:14Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/91362025-06-13T10:44:27Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_19597col_20.500.12105_19616col_20.500.12105_25179

00925njm 22002777a 4500 dc Abarrategi, Ander author Gambera, Stefano author Alfranca, Arantzazu author Rodriguez-Milla, Miguel A author Perez-Tavarez, Raquel author Rouault-Pierre, Kevin author Waclawiczek, Alexander author Chakravarty, Probir author Mulero, Francisca author Trigueros, César author Navarro, Samuel author Bonnet, Dominique author Garcia-Castro, Javier author 2018 Mesenchymal progenitor cells (MPCs) have been hypothesized as cells of origin for sarcomas, and c-Fos transcription factor has been showed to act as an oncogene in bone tumors. In this study, we show c-Fos is present in most sarcomas with chondral phenotype, while multiple other genes are related to c-Fos expression pattern. To further define the role of c-Fos in sarcomagenesis, we expressed it in primary human MPCs (hMPCs), immortalized hMPCs and transformed murine MPCs (mMPCs). In immortalized hMPCs, c-Fos expression generated morphological changes, reduced mobility capacity and impaired adipogenic- and osteogenic-differentiation potentials. Remarkably, immortalized hMPCs or mMPCs expressing c-Fos generated tumors harboring a chondrogenic phenotype and morphology. Thus, here we show that c-Fos protein has a key role in sarcomas and that c-Fos expression in immortalized MPCs yields cell transformation and chondrogenic tumor formation. Sci Rep. 2018 Oct 23;8(1):15615. 10.1038/s41598-018-33689-0 2045-2322 2045-2322 Scientific reports 30353072 http://hdl.handle.net/20.500.12105/9136 c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells