2026-06-14T05:06:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91352025-05-23T10:31:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Zaragoza, Oscar
funder
Ministerio de Ciencia e Innovación (España)
2020-02-21T10:58:41Z
2020-02-21T10:58:41Z
2011
Front Microbiol. 2011 Sep 6;2:181.
10.3389/fmicb.2011.00181
1664-302X
1664-302X
Frontiers in microbiology
21922016
http://hdl.handle.net/20.500.12105/9135
Although morphological transitions (such as hyphae and pseudohyphae formation) are a common feature among fungi, the encapsulated pathogenic yeast Cryptococcus neoformans is found during infection as blastoconidia. However, this fungus exhibits striking variations in cellular structure and size, which have important consequences during infection. This review will summarize the main aspects related with phenotypic and morphological variations in C. neoformans, which can be divided in three classes. Two of them are related to changes in the capsule, while the third one involves changes in the whole cell. The three morphological and phenotypic variations in C. neoformans can be classified as: (1) changes in capsule structure, (2) changes in capsule size, and (3) changes in the total size of the cell, which can be achieved by the formation of cryptococcal giant/titan cells or microforms. These changes have profound consequences on the interaction with the host, involving survival, phagocytosis escape and immune evasion and dissemination. This article will summarize the main features of these changes, and highlight their importance during the interaction with the host and how they contribute to the development of the disease.
eng
Cryptococcus neoformans
Antigenic variations
Capsule enlargement
Giant cells
Micro-cells
Morphogenesis
Multiple Disguises for the Same Party: The Concepts of Morphogenesis and Phenotypic Variations in Cryptococcus neoformans
research article
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URL
https://repisalud.isciii.es/bitstreams/fcab7151-fa37-4fa8-9b20-84bea2cfeef4/download
File
MD5
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application/pdf
MultipleDisguisesForThe_2011.pdf
URL
https://repisalud.isciii.es/bitstreams/3e763a4a-efbc-4d4d-804f-550e8ed4aee8/download
File
MD5
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text/plain
MultipleDisguisesForThe_2011.pdf.txt