2026-06-14T11:55:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91332024-11-28T15:54:12Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938
Repisalud
author
Mesa-Arango, Ana Cecilia
author
Scorzoni, Liliana
author
Zaragoza, Oscar
funder
Fundación Carolina
funder
Agencia Española de Cooperación Internacional para el Desarrollo
funder
Ministerio de Economía y Competitividad (España)
2020-02-21T10:58:18Z
2020-02-21T10:58:18Z
2012
Front Microbiol. 2012 Aug 8;3:286. eCollection
10.3389/fmicb.2012.00286
1664-302X
1664-302X
Frontiers in microbiology
23024638
http://hdl.handle.net/20.500.12105/9133
"Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol" is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells.
eng
Amphotericin B
Fungal infection
Immunomodulation
Oxidative damage
Pore
It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
journal article
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URL
https://repisalud.isciii.es/bitstreams/7ca923cd-f63f-49b8-ade8-9da912cb5c63/download
File
MD5
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application/pdf
ItOnlyTakesOne_2012.pdf
URL
https://repisalud.isciii.es/bitstreams/a950468b-276f-4257-93f6-94d860780719/download
File
MD5
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text/plain
ItOnlyTakesOne_2012.pdf.txt