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oai:repisalud.isciii.es:20.500.12105/91172024-09-27T18:16:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Tinkelman, Naomi E author Spratlen, Miranda Jones author Domingo-Relloso, Arce author Tellez-Plaza, Maria author Grau-Perez, Maria author Francesconi, Kevin A author Goessler, Walter author Howard, Barbara V author MacCluer, Jean author North, Kari E author Umans, Jason G author Factor-Litvak, Pam author Cole, Shelley A author Navas-Acien, Ana author 2020-02-11 Experimental and prospective epidemiologic evidence suggest that arsenic exposure has diabetogenic effects. However, little is known about how family exposure to arsenic may affect risk for type 2 diabetes (T2D)-related outcomes in adulthood. We evaluated the association of both maternal and offspring arsenic exposure with fasting glucose and incident T2D in 466 participants of the Strong Heart Family Study. Total arsenic (ΣAs) exposure was calculated as the sum of inorganic arsenic (iAs) and methylated (MMA, DMA) arsenic species in maternal and offspring baseline urine. Median maternal ΣAs at baseline (1989-91) was 7.6 µg/g creatinine, while median offspring ΣAs at baseline (2001-03) was 4.5 µg/g creatinine. Median offspring glucose in 2006-2009 was 94 mg/dL, and 79 participants developed T2D. The fully adjusted mean difference (95% CI) for offspring glucose was 4.40 (-3.46, 12.26) mg/dL per IQR increase in maternal ΣAs vs. 2.72 (-4.91 to 10.34) mg/dL per IQR increase in offspring ΣAs. The fully adjusted odds ratio (95%CI) of incident T2D was 1.35 (1.07, 1.69) for an IQR increase in maternal ΣAs and 1.15 (0.92, 1.43) for offspring ΣAs. The association of maternal ΣAs with T2D outcomes were attenuated with adjustment for offspring adiposity markers. Familial exposure to arsenic, as measured in mothers 15-20 years before offspring follow-up, is associated with increased odds of offspring T2D. More research is needed to confirm findings and better understand the importance of family exposure to arsenic in adult-onset diabetes. Environ Int. 2020 Feb 11;137:105531. http://hdl.handle.net/20.500.12105/9117 32059145 10.1016/j.envint.2020.105531 1873-6750 Environment international American Indians Arsenic Fasting glucose Indigenous populations Insulin resistance Prenatal exposures Prospective cohort studies Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study