2026-06-14T03:30:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91132024-09-27T21:54:44Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Velasco, María
author
Sánchez-Seco, María Paz
author
Campelo, Carolina
author
De Ory, Fernando de
author
Martin, Oriol
author
Herrero-Romero, Laura
author
Salmerón Béliz, Octavio J
author
Minguito, Teodora
author
Campos, Mª Carmen
author
Molero-Sanz, Francisca
author
Algora, Alejandro
author
Vazquez, Ana
funder
Instituto de Salud Carlos III
2020-02-19T08:16:41Z
2020-02-19T08:16:41Z
2020-01-29
Viruses. 2020 Jan 29;12(2). pii: E156.
10.3390/v12020156
1999-4915
1999-4915
Viruses
32013149
http://hdl.handle.net/20.500.12105/9113
We report the first human case of West Nile virus (WNV) lineage 2 infection imported to Spain by a traveler returning from Romania. Serum, cerebrospinal fluid and urine samples were analyzed and West Nile virus infection was identified by PCR and serological tests. The patient developed fever, diarrhea and neurological symptoms, accompanied by mild pancreatitis, described previously in very few cases as a complication of WNV infection and by alithiasic cholecystitis. Viral RNA was detected in urine until 30 days after the onset of symptoms and neutralizing antibodies were detected at very low titers. The phylogenetic analysis in a fragment of the NS5 gene of the virus showed a homology with sequences from WNV lineage 2 belonging to the monophyletic Central/Southern European group.
eng
Spain
West Nile virus lineage 2
Digestive complications
Human
Neurological symptoms
Imported Human West Nile Virus Lineage 2 Infection in Spain: Neurological and Gastrointestinal Complications
journal article
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URL
https://repisalud.isciii.es/bitstreams/e2cb9e21-c6da-40f7-864a-4f37a4621777/download
File
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application/pdf
ImportedHumanWestNile_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/5a68e652-dd1d-4157-bb42-cddb3b900ec8/download
File
MD5
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ImportedHumanWestNile_2020.pdf.txt