2026-06-14T03:37:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/91122025-04-08T10:38:06Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16958col_20.500.12105_16969
Repisalud
author
Casado, Concepcion
author
Gálvez, Cristina
author
Pernas, Maria
author
Tarancon-Diez, Laura
author
Rodriguez, Carmen
author
Sanchez-Merino, Victor
author
Vera, Mar
author
Olivares, Isabel
author
De Pablo-Bernal, Rebeca
author
Merino-Mansilla, Alberto
author
Del Romero, Jorge
author
Lorenzo-Redondo, Ramon
author
Ruiz-Mateos, Ezequiel
author
Salgado, María
author
Martinez-Picado, Javier
author
Lopez-Galindez, Luis Cecilio
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Regional Government of Andalusia (España)
2020-02-19T08:16:30Z
2020-02-19T08:16:30Z
2020-02-05
Sci Rep. 2020 Feb 5;10(1):1902.
10.1038/s41598-020-58696-y
2045-2322
2045-2322
Scientific reports
32024974
http://hdl.handle.net/20.500.12105/9112
Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. We define exceptional EC (EEC) as HIV-1 subjects who maintain the EC characteristics without disease progression for more than 25 years. We analyzed three EEC, diagnosed between 1988 and 1992, who never showed signs of clinical disease progression in absence of any antiretroviral treatment. A comprehensive clinical, virological, and immunological study was performed. The individuals simultaneously exhibited ≥3 described host protective alleles, low levels of total HIV-1 DNA (<20 copies/106 CD4+ T-cells) without evidence of replication-competent viruses (<0.025 IUPM), consistent with high levels of defective genomes, strong cellular HIV-1-specific immune response, and a high poly-functionality index (>0.50). Inflammation levels of EEC were similar to HIV-1 negative donors. Remarkably, they showed an exceptional lack of viral evolution and 8-fold lower genetic diversity (<0.01 s/n) in env gene than other EC. We postulate that these EEC represent cases of spontaneous functional HIV-1 cure. A non-functional and non-genetically evolving viral reservoir along with an HIV-1-specific immune response seems to be key for the spontaneous functional cure.
eng
Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure
research article
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URL
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PermanentControlOfHIV_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/209a610a-317d-457a-b45d-73165f806c15/download
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PermanentControlOfHIV_2020.pdf.txt